Journal:

Article Title: Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma

doi: 10.1158/1940-6207.CAPR-10-0249

Figure Lengend Snippet: Incidence of premalignant and malignant lesions in control, erlotinib and guggulipid-treated groups. H&E stained sections of tongues harvested from mice in each group were examined for the presence of premalignant (moderate and high grade dysplasia) plus malignant lesions. The group treated with erlotinib demonstrated a decrease in numbers of such lesions (p<0.001).

Article Snippet: Guggulipid (solid, 2.65% guggulsterones by hplc) was generously provided by Sabinsa Corporation (Piscataway, NJ) and erlotinib by OSI Pharmaceuticals (New York, NY).

Techniques: Control, Staining

Journal:

Article Title: Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma

doi: 10.1158/1940-6207.CAPR-10-0249

Figure Lengend Snippet: STAT3 levels in 4-NQO-induced dysplasia. Photomicrographs of the dysplastic lesions with the median immunostain score for each group, occurring in tongues of animals from the vehicle (A), erlotinib (B) and guggulipid (C)-treated groups stained for STAT3. D. Graphical description of immunostain scores for each group (p= 0.11 for vehicle versus erlotinib and p = 0.41 for vehicle versus guggulipid).

Article Snippet: Guggulipid (solid, 2.65% guggulsterones by hplc) was generously provided by Sabinsa Corporation (Piscataway, NJ) and erlotinib by OSI Pharmaceuticals (New York, NY).

Techniques: Staining

Journal: Frontiers in Molecular Biosciences

Article Title: Mapping of Brain Activity in the Analgesia Induced by Ph α 1 β and Morphine

doi: 10.3389/fmolb.2021.770471

Figure Lengend Snippet: Purification of Ph αβ from the venom of the spider P. nigriventer (A) Reverse phase of the crude venom of Phoneutria nigriventer spider in column C4 Vydac. (B) Cation exchange HPLC of the fraction Phαβ from (A) on Hi trap Sp Hp column (C) Reverse phase desalting of Phαβ from (B) in a column C18 small pore (arrow indicates the peak used in each step) (D) Mass spectra of the Phαβ MS obtained on MALDI/TOF in positive/linear mode (laser frequency 100%, mass range 2–20,000 ( m/ z).

Article Snippet: We collected three fractions (A–C; ), and fraction C was dissolved in 1 ml of 10 mM sodium phosphate buffer, pH 6.5, and fractionated on a weak cation exchange HPLC column (4.6 mm _ 25 cm) of Synchropak CM 300 (Synchrom Inc, Lafayette, IN) equilibrated in the same buffer.

Techniques: Purification